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method of wet grinding pharmaceutical substances:

US5862999A - Method of grinding pharmaceutical substances ...

A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.

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US5518187A - Method of grinding pharmaceutical substances ...

A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.

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Method of grinding pharmaceutical substances - Nano ...

The particles are prepared by dispersing a drug substance or contrast agent in a liquid dispersion medium and wet grinding in the presence of rigid grinding media. Particles free of unacceptable contamination have been prepared in accordance with this method.

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More safety and flexibility through wet grinding A fluid ...

Sep 01, 2010  Dry grinding of organic substances requires elaborate exhaust and filter fans that are meant to avert the danger of dust explosions. Wet grinding processes offer an efficient alternative and are able to achieve even very small particle sizes. Heavy-duty dispersing machines such as the Dispax DR 2000 and DRS 2000 Reactors boast various advantages: closed []

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Wet Grinding - NETZSCH Grinding Dispersing

Finest wet grinding technology – the laboratory mills of the MicroSeries are an investment in the future for new product developments of different fields of application of pigmented ink jets, technical ceramics, cosmetics, pharmaceutical applications and nano-scale high-tech products.

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EP0804161B1 - Continuous method of grinding pharmaceutical ...

Continuous method of grinding pharmaceutical substances Download PDF Info Publication number EP0804161B1. EP0804161B1 EP19950919062 EP95919062A EP0804161B1 EP 0804161 B1 EP0804161 B1 EP 0804161B1 EP 19950919062 EP19950919062 EP 19950919062 EP 95919062 A EP95919062 A EP 95919062A EP 0804161 B1 EP0804161 B1 EP 0804161B1

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US5718388A - Continuous method of grinding pharmaceutical ...

A continuous method of preparing submicron particles of a therapeutic or diagnostic agent comprises the steps of continuously introducing the agent and rigid grinding media into a

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Continuous method of grinding pharmaceutical substances ...

The particles are prepared by dispersing a drug substance or imaging agent in a liquid dispersion medium and wet grinding in the presence of rigid grinding media. Liversidge et al do not suggest a continuous milling process wherein the grinding media is separated from the pharmaceutical agent outside the milling chamber.

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ES2318693T5 - Wet granulation process for the preparation ...

Teva Pharmaceutical Industries Ltd Original Assignee Teva Pharmaceutical Industries Ltd Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) 2006-01-05 Filing date 2006-03-14 Publication date 2018-10-04

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Testing a Benchtop Wet-Milling Method for Preparing ...

In hospital formulations, the active substances from commercial products have been often used as active pharmaceutical ingredients (APIs). However, more than 40% of pharmaceutical compounds have extremely poor water solubility [1,2].To develop a method

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More safety and flexibility through wet grinding A fluid ...

Sep 01, 2010  Dry grinding of organic substances requires elaborate exhaust and filter fans that are meant to avert the danger of dust explosions. Wet grinding processes offer an efficient alternative and are able to achieve even very small particle sizes. Heavy

Read More
Method of grinding pharmaceutical substances - Patent ...

A method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.

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METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES -

A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin.

Read More
Testing a Benchtop Wet-Milling Method for Preparing ...

In hospital formulations, the active substances from commercial products have been often used as active pharmaceutical ingredients (APIs). However, more than 40% of pharmaceutical compounds have extremely poor water solubility [1,2].To develop a method

Read More
METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES -

METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES (PAT - EP0760653) CZEKAI David A., SEAMAN Larry P. NanoSystems L.L.C. Patent: Publ. of Application with search report - European Patent Office. Application: EP19950919828 on 1995-05-12 Publication: 1997-03-12. Abstract: Highlight Terms ...

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CONTINUOUS METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES ...

The method enables the use of fine grinding media, e.g., of a particle size of less than about 300 'mu'm, in a continuous grinding process which provides extremely fine particles of the agent, e.g., particles less than 100 nm in size, while avoiding problems, e.g., separator screen plugging, associated with prior art processes requiring the ...

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Wet Grinding - NETZSCH Grinding Dispersing

Finest wet grinding technology – the laboratory mills of the MicroSeries are an investment in the future for new product developments of different fields of application of pigmented ink jets, technical ceramics, cosmetics, pharmaceutical applications and nano-scale high-tech products.

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WO2003090714A1 - Method for the production of crystals ...

Disclosed is a method for producing crystals, the average particle size of which lies within a predefined range while the maximum particle size does not exceed a given value. According to the inventive method, an oversaturated solution of special 11ß-benzaldoxime-estra-4,9-diene is subjected to wet milling during crystallization by means of a wet milling device, whereby a primary granular ...

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How Are Pharmaceutical Creams Made? Trainingsadda

Levigation Method. Through the use of water, levigation process grinds an insoluble substance into a crushed, fine powder. Thus, it is also known as ‘wet grinding’. This powder stays on the water, flowing through the apparatus as it serves as a murky liquid or paste.

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(PDF) Solid dispersion in pharmaceutical technology. Part ...

of poorly soluble substances from given pharmaceutical . ... by melting method) of the substance in poloxamer 188 ... was obtained by wet grinding of the crystalline tranilast .

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An Analysis of the Technical and Economic Influences of ...

Particle size control is of vital importance to the performance and manufacturability of a solid drug substance used in an oral dosage pharmaceutical product. Numerous options for control are available to engineers and scientists engaged in process design; this study seeks to demonstrate the steps taken to define the optimal solution. Wet milling, terminal size control though crystallisation ...

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Size reduction_Pharmaceutical engineering

Jun 03, 2014  In the case of water insoluble substances, wet grinding of the material can be done. For the preparation of aqueous dispersions of drugs this method is very effective since deflocculating agents may be included to prevent agglomeration of the particles.

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Pharmaceutical nanocrystals: production by wet milling and ...

Wet milling is a scalable method applicable to drugs with different physicochemical and mechanical properties. Nanocrystalline-based formulations, either as liquid nanosuspensions or after downstream processing to solid dosage forms, have been developed as drug delivery systems for various routes of administration (i.e., oral, parenteral ...

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(PDF) METHODS OF SIZE REDUCTION AND FACTORS AFFECTING SIZE ...

At these settings, predicted values of grinding capacity, grinding recovery, and APD are 142.3 kg h-1, 100% and 0.494 mm, respectively. End-user requirements for fine grinding and good machine ...

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More safety and flexibility through wet grinding A fluid ...

Sep 01, 2010  Dry grinding of organic substances requires elaborate exhaust and filter fans that are meant to avert the danger of dust explosions. Wet grinding processes offer an efficient alternative and are able to achieve even very small particle sizes. Heavy

Read More
Method of grinding pharmaceutical substances - Patent ...

A method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.

Read More
METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES -

A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin.

Read More
METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES -

METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES (PAT - EP0760653) CZEKAI David A., SEAMAN Larry P. NanoSystems L.L.C. Patent: Publ. of Application with search report - European Patent Office. Application: EP19950919828 on 1995-05-12 Publication: 1997-03-12. Abstract: Highlight Terms ...

Read More
CONTINUOUS METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES ...

The method enables the use of fine grinding media, e.g., of a particle size of less than about 300 'mu'm, in a continuous grinding process which provides extremely fine particles of the agent, e.g., particles less than 100 nm in size, while avoiding problems, e.g., separator screen plugging, associated with prior art processes requiring the ...

Read More
Wet Grinding - NETZSCH Grinding Dispersing

Finest wet grinding technology – the laboratory mills of the MicroSeries are an investment in the future for new product developments of different fields of application of pigmented ink jets, technical ceramics, cosmetics, pharmaceutical applications and nano-scale high-tech products.

Read More
Size reduction_Pharmaceutical engineering

Jun 03, 2014  In the case of water insoluble substances, wet grinding of the material can be done. For the preparation of aqueous dispersions of drugs this method is very effective since deflocculating agents may be included to prevent agglomeration of the particles.

Read More
How Are Pharmaceutical Creams Made? Trainingsadda

Levigation Method. Through the use of water, levigation process grinds an insoluble substance into a crushed, fine powder. Thus, it is also known as ‘wet grinding’. This powder stays on the water, flowing through the apparatus as it serves as a murky liquid or paste.

Read More
An Analysis of the Technical and Economic Influences of ...

Particle size control is of vital importance to the performance and manufacturability of a solid drug substance used in an oral dosage pharmaceutical product. Numerous options for control are available to engineers and scientists engaged in process design; this study seeks to demonstrate the steps taken to define the optimal solution. Wet milling, terminal size control though crystallisation ...

Read More
(PDF) Solid dispersion in pharmaceutical technology. Part ...

of poorly soluble substances from given pharmaceutical . ... by melting method) of the substance in poloxamer 188 ... was obtained by wet grinding of the crystalline tranilast .

Read More
Nano Sizing Via Wet or Dry Grinding powderbulksolids

Recent developments in particle reduction technology have enabled the production of nanoparticles through a dry-grinding method using steam. Considering the advantages and applications of each method described below will enable the client to choose the most appropriate method and equipment to achieve the desired results. ... some substances ...

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(PDF) METHODS OF SIZE REDUCTION AND FACTORS AFFECTING SIZE ...

At these settings, predicted values of grinding capacity, grinding recovery, and APD are 142.3 kg h-1, 100% and 0.494 mm, respectively. End-user requirements for fine grinding and good machine ...

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Tablet Manufacture by Wet Granulation Method ...

Wet granulation method of tablet production involves the following processing steps: Step 1: Weighing and mixing of formulation ingredients (excluding the lubricant). This step involves the weighing, sifting and introduction of specified quantities of drug substance(s), bulking agent, filler or diluent, and disintegrant into a powder mixer.

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Size reduction - SlideShare

Dec 05, 2019  The material having 5% moisture in case of dry grinding and 50% moisture in wet grinding does not create any problem. 6. Softening temperature : Waxy substances such as stearic acid or drugs containing oils or fats, become softened during the size reduction processes, if

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